| Short Description : | Rabbit polyclonal AP3S2 (1-193) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AP3S2 |
| Gene ID: | 10239 |
| Uniprot ID: | AP3S2_HUMAN |
| Immunogen Region: | 1-193 |
| Immunogen Sequence: | MIQAILVFNNHGKPRLVRFY QRFPEEIQQQIVRETFHLVL KRDDNICNFLEGGSLIGGSD YKLIYRHYATLYFVFCVDSS ESELGILDLIQVFVETLDKC FENVCELDLIFHMDKVHYIL QEVVMGGMVLETNMNEIVAQ IEAQNRLEKSEGGLSAAPAR AVSAVKNINLPEIPRNINIG DLNIKVPNLSQFV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human AP3S2 (NP_005820.1). |
| Tissue Specificity | Present in all adult tissues examined. |
| Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Protein Name | Ap-3 Complex Subunit Sigma-2Ap-3 Complex Subunit Sigma-3bAdaptor-Related Protein Complex 3 Subunit Sigma-2Sigma-3b-AdaptinSigma3b-AdaptinSigma-Adaptin 3b |
| Database Links | |
| Cellular Localisation | Golgi ApparatusCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideComponent Of The Coat Surrounding The Cytoplasmic Face Of Coated Vesicles Located At The Golgi Complex |
| Alternative Antibody Names | Anti-Ap-3 Complex Subunit Sigma-2 antibodyAnti-Ap-3 Complex Subunit Sigma-3b antibodyAnti-Adaptor-Related Protein Complex 3 Subunit Sigma-2 antibodyAnti-Sigma-3b-Adaptin antibodyAnti-Sigma3b-Adaptin antibodyAnti-Sigma-Adaptin 3b antibodyAnti-AP3S2 antibody |
Information sourced from Uniprot.org
