| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANXA2 |
| Gene ID: | 302 |
| Uniprot ID: | ANXA2_HUMAN |
| Immunogen Region: | 1-339 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human Annexin A2 (NP_004030.1). |
| Immunogen Sequence: | MSTVHEILCKLSLEGDHSTP PSAYGSVKAYTNFDAERDAL NIETAIKTKGVDEVTIVNIL TNRSNAQRQDIAFAYQRRTK KELASALKSALSGHLETVIL GLLKTPAQYDASELKASMKG LGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDII SDTSGDFRKLMVALAKGRRA EDGSVIDYELIDQDARDLYD AGVKRKGTDVPKWISIMTER SVPHLQKVFDRYKSYSPYD |
| Post Translational Modifications | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Annexin A2 Annexin Ii Annexin-2 Calpactin I Heavy Chain Calpactin-1 Heavy Chain Chromobindin-8 Lipocortin Ii Placental Anticoagulant Protein Iv Pap-Iv Protein I P36 |
| Database Links | Reactome: R-HSA-445355 Reactome: R-HSA-6798695 Reactome: R-HSA-75205 Reactome: R-HSA-8950505 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Basement Membrane Melanosome In The Lamina Beneath The Plasma Membrane Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv Translocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism |
| Alternative Antibody Names | Anti-Annexin A2 antibody Anti-Annexin Ii antibody Anti-Annexin-2 antibody Anti-Calpactin I Heavy Chain antibody Anti-Calpactin-1 Heavy Chain antibody Anti-Chromobindin-8 antibody Anti-Lipocortin Ii antibody Anti-Placental Anticoagulant Protein Iv antibody Anti-Pap-Iv antibody Anti-Protein I antibody Anti-P36 antibody Anti-ANXA2 antibody Anti-ANX2 antibody Anti-ANX2L4 antibody Anti-CAL1H antibody Anti-LPC2D antibody |
Information sourced from Uniprot.org