Anti-ANO2 antibody (1-200) (STJ116212)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ANO2 (1-200) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANO2 |
| Gene ID | 57101 |
| Uniprot ID | ANO2_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MPEDIPLLPGSPRRLSPQAG SRGGQGPKHGQQCLKMPGPR APGLQGGSNRDPGQPCGGES TRSSSVINNYLDANEPVSLE ARLSRMHFHDSQRKVDYVLA YHYRKRGVHLAQGFPGHSLA IVSNGETGKEPHAGGPGDIE LGPLDALEEERKEQREEFEH NLMEAGLELEKDLENKSQGS IFVRIHAPWQVLAREAEFLK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_001265526.1). |
Additional Info
| Tissue Specificity | Retina, especially in the photoreceptor synaptic terminals. |
| Function | Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. |
| Protein Name | Anoctamin-2Transmembrane Protein 16b |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-381753Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Anoctamin-2 antibodyAnti-Transmembrane Protein 16b antibodyAnti-ANO2 antibodyAnti-C12orf3 antibodyAnti-TMEM16B antibody |
Information sourced from Uniprot.org