| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANO2 |
| Gene ID: | 57101 |
| Uniprot ID: | ANO2_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_001265526.1). |
| Immunogen Sequence: | MPEDIPLLPGSPRRLSPQAG SRGGQGPKHGQQCLKMPGPR APGLQGGSNRDPGQPCGGES TRSSSVINNYLDANEPVSLE ARLSRMHFHDSQRKVDYVLA YHYRKRGVHLAQGFPGHSLA IVSNGETGKEPHAGGPGDIE LGPLDALEEERKEQREEFEH NLMEAGLELEKDLENKSQGS IFVRIHAPWQVLAREAEFLK |
| Tissue Specificity | Retina, especially in the photoreceptor synaptic terminals. |
| Function | Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. |
| Protein Name | Anoctamin-2Transmembrane Protein 16b |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-381753Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Anoctamin-2 antibodyAnti-Transmembrane Protein 16b antibodyAnti-ANO2 antibodyAnti-C12orf3 antibodyAnti-TMEM16B antibody |
Information sourced from Uniprot.org