| Post Translational Modifications | Ubiquitinated by the ECS(RAB40C) complex leading to its degradation and decreased PP6 activity. |
| Function | Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration. |
| Protein Name | Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit APp6-Ars-ASerine/Threonine-Protein Phosphatase 6 Regulatory Subunit Ars-AAnkyrin Repeat Domain-Containing Protein 28Phosphatase Interactor Targeting Protein Hnrnp KPitk |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-204005 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmCytosolCell ProjectionLamellipodiumSeems To Be Excluded From NucleoliMostly Localized In The CytosolBut A Fraction Could Be Observed At The Lamellipodia |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit A antibodyAnti-Pp6-Ars-A antibodyAnti-Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit Ars-A antibodyAnti-Ankyrin Repeat Domain-Containing Protein 28 antibodyAnti-Phosphatase Interactor Targeting Protein Hnrnp K antibodyAnti-Pitk antibodyAnti-ANKRD28 antibodyAnti-KIAA0379 antibody |
Information sourced from Uniprot.org
