| Host: |
Goat |
| Applications: |
Pep-ELISA/IF |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ANILLIN/Scraps (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ANLN |
| Gene ID: |
54443 |
| Uniprot ID: |
ANLN_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_061155.2 |
| Immunogen Sequence: |
TYPDDEKRKNP |
| Post Translational Modifications | Phosphorylated during mitosis. Ubiquitinated, and this requires FZR1/CDH1. |
| Function | Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration. |
| Protein Name | Anillin |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonCell CortexCell ProjectionBlebMainly Found In The Nucleus During InterphaseColocalizes With Cortical F-Actin Upon Nuclear Envelope Breakdown In Mitosis And Subsequently Concentrates In The Area Of The Prospective Contractile Ring In AnaphaseThis Pattern Persists Until TelophaseWhen The Protein Becomes Concentrated In The Midbody |
| Alternative Antibody Names | Anti-Anillin antibodyAnti-ANLN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
