Anti-ANGPTL4 antibody (301-350 aa) (STJ96539)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ANGPTL4 at the amino acid range 301-350
General Information
| Short Description | Rabbit polyclonal anti-Angiopoietin-related protein 4 (301-350 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 100-300WB 1:500-1:2000ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANGPTL4 |
| Gene ID | 51129 |
| Uniprot ID | ANGL4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ANGPTL4 at the amino acid range 301-350 |
| Immunogen Region | 301-350 aa |
| Specificity | Angptl4 Polyclonal Antibody detects endogenous levels of Angptl4 protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell. |
| Function | Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein. |
| Protein Name | Angiopoietin-Related Protein 4Angiopoietin-Like Protein 4Hepatic Fibrinogen/Angiopoietin-Related ProteinHfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381340Reactome: R-HSA-8963889Reactome: R-HSA-9762292Reactome: R-HSA-9841922 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixThe Unprocessed Form Interacts With The Extracellular MatrixThis May Constitute A Dynamic ReservoirA Regulatory Mechanism Of The Bioavailability Of Angptl4 (Probable) |
| Alternative Antibody Names | Anti-Angiopoietin-Related Protein 4 antibodyAnti-Angiopoietin-Like Protein 4 antibodyAnti-Hepatic Fibrinogen/Angiopoietin-Related Protein antibodyAnti-Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain antibodyAnti-ANGPTL4 antibodyAnti-ARP4 antibodyAnti-HFARP antibodyAnti-PGAR antibodyAnti-PP1158 antibodyAnti-PSEC0166 antibodyAnti-UNQ171 antibodyAnti-PRO197 antibody |
Information sourced from Uniprot.org