| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-ANAPC11 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | WB-0.3-1µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ANAPC11 |
| Gene ID: | 51529 |
| Uniprot ID: | APC11_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001002244.1; NP_057560.8 |
| Specificity: | This antibody is expected to recognize. Reported variants represent identical protein: NP_057560.8, NP_001002248.1, NP_001002245.1, NP_001002246.1, NP_001002247.1, NP_001002249.1 |
| Immunogen Sequence: | PALDQETSSLLRCTS |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Protein Name | Anaphase-Promoting Complex Subunit 11Apc11Cyclosome Subunit 11Hepatocellular Carcinoma-Associated Ring Finger Protein |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 11 antibodyAnti-Apc11 antibodyAnti-Cyclosome Subunit 11 antibodyAnti-Hepatocellular Carcinoma-Associated Ring Finger Protein antibodyAnti-ANAPC11 antibodyAnti-HSPC214 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
