| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Angiomotin (1000-1084) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMOT |
| Gene ID: |
154796 |
| Uniprot ID: |
AMOT_HUMAN |
| Immunogen Region: |
1000-1084 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1000-1084 of human AMOT (NP_001106962.1). |
| Immunogen Sequence: |
QTQAPTSAPAVAPTPAPTPT PAVAQAEVPASPATGPGPHR LSIPSLTCNPDKTDGPVFHS NTLERKTPIQILGQEPDAEM VEYLI |
| Tissue Specificity | Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. |
| Post Translational Modifications | Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. |
| Function | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. |
| Protein Name | Angiomotin |
| Database Links | Reactome: R-HSA-2028269 Q4VCS5-1Reactome: R-HSA-9762292 Q4VCS5-2 |
| Cellular Localisation | Cell JunctionTight JunctionLocalized On The Cell SurfaceMay Act As A Transmembrane Protein |
| Alternative Antibody Names | Anti-Angiomotin antibodyAnti-AMOT antibodyAnti-KIAA1071 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
