Anti-AMD1 antibody (75-334) (STJ11103623)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AMD1 (75-334) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AMD1 |
| Gene ID | 262 |
| Uniprot ID | DCAM_HUMAN |
| Immunogen Region | 75-334 |
| Immunogen Sequence | RRFILKTCGTTLLLKALVPL LKLARDYSGFDSIQSFFYSR KNFMKPSHQGYPHRNFQEEI EFLNAIFPNGAAYCMGRMNS DCWYLYTLDFPESRVISQPD QTLEILMSELDPAVMDQFYM KDGVTAKDVTRESGIRDLIP GSVIDATMFNPCGYSMNGMK SDGTYWTIHITPEPEFSYVS FETNLSQTSYDDLIRKVVEV FKPGKFVTTLFVNQSSKCRT VLASPQKIEGFKRLDCQSA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human AMD1 (NP_001625.2). |
Additional Info
| Post Translational Modifications | Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. |
| Function | Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. |
| Protein Name | S-Adenosylmethionine Decarboxylase ProenzymeAdometdcSamdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain |
| Database Links | Reactome: R-HSA-351202 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-S-Adenosylmethionine Decarboxylase Proenzyme antibodyAnti-Adometdc antibodyAnti-Samdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain antibodyAnti-AMD1 antibodyAnti-AMD antibody |
Information sourced from Uniprot.org