| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ALPK1 (340-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALPK1 |
| Gene ID: |
80216 |
| Uniprot ID: |
ALPK1_HUMAN |
| Immunogen Region: |
340-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 340-500 of human ALPK1 (NP_001095876.1). |
| Immunogen Sequence: |
RDDEPVTGKQELHSFVKAAF GLTTVHRRLHGETGTVHAAS QLCKEAMGKLYNFSTSSRSQ DREALSQEVMSVIAQVKEHL QVQSFSNVDDRSYVPESFEC RLDKLILHGQGDFQKILDTY SQHHTSVCEVFESDCGNNKN EQKDAKTGVCITALKTEIKN I |
| Tissue Specificity | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina. |
| Function | Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis. |
| Protein Name | Alpha-Protein Kinase 1Chromosome 4 KinaseLymphocyte Alpha-Protein Kinase |
| Database Links | Reactome: R-HSA-445989Reactome: R-HSA-9645460 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonSpindle PoleMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumLocalized At The Base Of Primary Cilia |
| Alternative Antibody Names | Anti-Alpha-Protein Kinase 1 antibodyAnti-Chromosome 4 Kinase antibodyAnti-Lymphocyte Alpha-Protein Kinase antibodyAnti-ALPK1 antibodyAnti-KIAA1527 antibodyAnti-LAK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
