| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Alkylated DNA repair protein alkB homolog 8-5-O-methyltransferase ABH8 (27-77) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALKBH8 |
| Gene ID: |
91801 |
| Uniprot ID: |
ALKB8_HUMAN |
| Immunogen Region: |
27-77 |
| Specificity: |
This antibody detects endogenous levels of human ALKB8 |
| Immunogen: |
Synthesized peptide derived from human ALKB8 AA range: 27-77 |
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine.has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
| Protein Name | Alkylated Dna Repair Protein Alkb Homolog 8Probable Alpha-Ketoglutarate-Dependent Dioxygenase Abh8S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Abh8TrnaCarboxymethyluridine(34-5-O-Methyltransferase Abh8 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Alkylated Dna Repair Protein Alkb Homolog 8 antibodyAnti-Probable Alpha-Ketoglutarate-Dependent Dioxygenase Abh8 antibodyAnti-S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Abh8 antibodyAnti-Trna antibodyAnti-Carboxymethyluridine(34-5-O-Methyltransferase Abh8 antibodyAnti-ALKBH8 antibodyAnti-ABH8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
