Immunofluorescence analysis of A549 cells using ALKBH4 antibody (STJ114467). Blue: DAPI for nuclear staining.

Anti-ALKBH4 antibody (1-302) (STJ114467)

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STJ114467
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Covered by St John's Laboratory Guarantee

Applications:WB/IF/ICC/ELISA
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:2000
IF/ICC:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:ALKBH4
Gene ID:54784
Uniprot ID:ALKB4_HUMAN
Immunogen Region:1-302
Immunogen Sequence:MAAAAAETPEVLRECGCKGI RTCLICERQRGSDPPWELPP AKTYRFIYCSDTGWAVGTEE SDFEGWAFPFPGVMLIEDFV TREEEAELVRLMDRDPWKLS QSGRRKQDYGPKVNFRKQKL KTEGFCGLPSFSREVVRRMG LYPGLEGFRPVEQCNLDYCP ERGSAIDPHLDDAWLWGERL VSLNLLSPTVLSMCREAPGS LLLCSAPSAAPEALVDSVIA PSRSVLCQEVEVAIPLPAR
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1).
Tissue Specificity Widely expressed, with highest expression in pancreas, ovary and spleen.
Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Protein Name Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
Alkylated Dna Repair Protein Alkb Homolog 4
Dna N6-Methyl Adenine Demethylase Alkbh4
Lysine-Specific Demethylase Alkbh4
Database Links
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Midbody
Associates With The Contractile Ring And Midbody
Alternative Antibody Names Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 antibody
Anti-Alkylated Dna Repair Protein Alkb Homolog 4 antibody
Anti-Dna N6-Methyl Adenine Demethylase Alkbh4 antibody
Anti-Lysine-Specific Demethylase Alkbh4 antibody
Anti-ALKBH4 antibody
Anti-ABH4 antibody

Information sourced from Uniprot.org

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