| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ALKBH4 (1-302) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALKBH4 |
| Gene ID: |
54784 |
| Uniprot ID: |
ALKB4_HUMAN |
| Immunogen Region: |
1-302 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1). |
| Immunogen Sequence: |
MAAAAAETPEVLRECGCKGI RTCLICERQRGSDPPWELPP AKTYRFIYCSDTGWAVGTEE SDFEGWAFPFPGVMLIEDFV TREEEAELVRLMDRDPWKLS QSGRRKQDYGPKVNFRKQKL KTEGFCGLPSFSREVVRRMG LYPGLEGFRPVEQCNLDYCP ERGSAIDPHLDDAWLWGERL VSLNLLSPTVLSMCREAPGS LLLCSAPSAAPEALVDSVIA PSRSVLCQEVEVAIPLPAR |
| Tissue Specificity | Widely expressed, with highest expression in pancreas, ovary and spleen. |
| Function | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4Alkylated Dna Repair Protein Alkb Homolog 4Dna N6-Methyl Adenine Demethylase Alkbh4Lysine-Specific Demethylase Alkbh4 |
| Cellular Localisation | CytoplasmNucleusNucleolusMidbodyAssociates With The Contractile Ring And Midbody |
| Alternative Antibody Names | Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 4 antibodyAnti-Dna N6-Methyl Adenine Demethylase Alkbh4 antibodyAnti-Lysine-Specific Demethylase Alkbh4 antibodyAnti-ALKBH4 antibodyAnti-ABH4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
