| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDH4A1 |
| Gene ID: | 8659 |
| Uniprot ID: | AL4A1_HUMAN |
| Immunogen Region: | 354-563 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 354-563 of human ALDH4A1 (NP_003739.2). |
| Immunogen Sequence: | LYVPHSLWPQIKGRLLEEHS RIKVGDPAEDFGTFFSAVID AKSFARIKKWLEHARSSPSL TILAGGKCDDSVGYFVEPCI VESKDPQEPIMKEEIFGPVL SVYVYPDDKYKETLQLVDST TSYGLTGAVFSQDKDVVQEA TKVLRNAAGNFYINDKSTGS IVGQQPFGGARASGTNDKPG GPHYILRWTSPQVIKETHKP LGDWSYAYMQ |
| Tissue Specificity | Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. |
| Function | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. |
| Protein Name | Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - MitochondrialP5c DehydrogenaseAldehyde Dehydrogenase Family 4 Member A1L-Glutamate Gamma-Semialdehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-70688 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - Mitochondrial antibodyAnti-P5c Dehydrogenase antibodyAnti-Aldehyde Dehydrogenase Family 4 Member A1 antibodyAnti-L-Glutamate Gamma-Semialdehyde Dehydrogenase antibodyAnti-ALDH4A1 antibodyAnti-ALDH4 antibodyAnti-P5CDH antibody |
Information sourced from Uniprot.org