| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-P4HTM (294-563) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
P4HTM |
| Gene ID: |
54681 |
| Uniprot ID: |
P4HTM_HUMAN |
| Immunogen Region: |
294-563 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 294-563 of human P4HTM (NP_808807.2). |
| Immunogen Sequence: |
RQRVLRLTRLSPEIVELSEP LQVVRYGEGGHYHAHVDSGP VYPETICSHTKLVANESVPF ETSCRQVSPNWGLPSILRPG TPMTQAQPCTVGVPLGMGPG DHWVIPVSPWEHPQLGTCSV PPLPYSYMTVLFYLNNVTGG GETVFPVADNRTYDEMSLIQ DDVDLRDTRRHCDKGNLRVK PQQGTAVFWYNYLPDGQGWV GDVDDYSLHGGCLVTRGTKW IANNWINVDPSRARQALFQ |
| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Protein Name | Transmembrane Prolyl 4-HydroxylaseP4h-TmHypoxia-Inducible Factor Prolyl Hydroxylase 4Hif-Ph4Hif-Prolyl Hydroxylase 4Hph-4 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Prolyl 4-Hydroxylase antibodyAnti-P4h-Tm antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 4 antibodyAnti-Hif-Ph4 antibodyAnti-Hif-Prolyl Hydroxylase 4 antibodyAnti-Hph-4 antibodyAnti-P4HTM antibodyAnti-PH4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
