| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S6MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDH1A2 |
| Gene ID: | 8854 |
| Uniprot ID: | AL1A2_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ALDH1A2 (NP_003879.2). |
| Immunogen Sequence: | MTSSKIEMPGEVKADPAALM ASLHLLPSPTPNLEIKYTKI FINNEWQNSESGRVFPVYNP ATGEQVCEVQEADKADIDKA VQAARLAFSLGSVWRRMDAS |
| Function | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral. |
| Protein Name | Retinal Dehydrogenase 2 Raldh 2 Raldh2 Aldehyde Dehydrogenase Family 1 Member A2 Aldh1a2 Retinaldehyde-Specific Dehydrogenase Type 2 Raldh(Ii |
| Database Links | Reactome: R-HSA-5365859 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Retinal Dehydrogenase 2 antibody Anti-Raldh 2 antibody Anti-Raldh2 antibody Anti-Aldehyde Dehydrogenase Family 1 Member A2 antibody Anti-Aldh1a2 antibody Anti-Retinaldehyde-Specific Dehydrogenase Type 2 antibody Anti-Raldh(Ii antibody Anti-ALDH1A2 antibody Anti-RALDH2 antibody |
Information sourced from Uniprot.org