Anti-AK3L1 antibody [R08-2B2] (STJA0035110)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human AK3L1
General Information
| Short Description | Rabbit monoclonal anti-AK3L1 for use in WB, IHC-F, IHC-P, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-2B2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | AK4 |
| Gene ID | 205 |
| Uniprot ID | KAD4_HUMAN |
| Immunogen | A synthetic peptide of human AK3L1 |
Additional Info
| Tissue Specificity | Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. |
| Function | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress. |
| Protein Name | Adenylate Kinase 4 - MitochondrialAdenylate Kinase 3-LikeGtp -Amp Phosphotransferase Ak4 |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Adenylate Kinase 4 - Mitochondrial antibodyAnti-Adenylate Kinase 3-Like antibodyAnti-Gtp -Amp Phosphotransferase Ak4 antibodyAnti-AK4 antibodyAnti-AK3 antibodyAnti-AK3L1 antibody |
Information sourced from Uniprot.org