| Short Description : | Rabbit polyclonal anti-Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AIMP2 |
| Gene ID: | 7965 |
| Uniprot ID: | AIMP2_HUMAN |
| Immunogen: | Synthesized peptide derived from human JTV1 |
| Specificity: | This antibody detects endogenous levels of JTV1 at Human, Mouse, Rat |
| Function | Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2Multisynthase Complex Auxiliary Component P38Protein Jtv-1 |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmCytosolNucleusFollowing Dna DamageDissociates From The Aminoacyl-Trna Synthase Complex And Translocates From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 antibodyAnti-Multisynthase Complex Auxiliary Component P38 antibodyAnti-Protein Jtv-1 antibodyAnti-AIMP2 antibodyAnti-JTV1 antibodyAnti-PRO0992 antibody |
Information sourced from Uniprot.org
