| Post Translational Modifications | Phosphorylated on serine residues in response to UV irradiation. Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease. |
| Function | Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2Multisynthase Complex Auxiliary Component P38Protein Jtv-1 |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmCytosolNucleusFollowing Dna DamageDissociates From The Aminoacyl-Trna Synthase Complex And Translocates From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 antibodyAnti-Multisynthase Complex Auxiliary Component P38 antibodyAnti-Protein Jtv-1 antibodyAnti-AIMP2 antibodyAnti-JTV1 antibodyAnti-PRO0992 antibody |
Information sourced from Uniprot.org
