| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-AIBZIP/CREB3L4 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-Recommended for use at 0.5-2µg/mlIHC-Recommended concentration, 2-4µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CREB3L4 |
| Gene ID: |
148327 |
| Uniprot ID: |
CR3L4_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_570968.1; NP_001242909.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_570968.1; NP_001242909.1). Reported variants represent identical protein: NP_001242908.1, NP_570968.1, NP_001242907.1 Reported variants represent identical protein: NP_001242909.1, NP_ |
| Immunogen Sequence: |
PSGRIRSVLHADEM |
| Post Translational Modifications | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-TGTACGTGAGT-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4Camp-Responsive Element-Binding Protein 3-Like Protein 4Androgen-Induced Basic Leucine Zipper ProteinAibzipAttaching To Cre-Like 1Atce1Cyclic Amp-Responsive Element-Binding Protein 4Creb-4Camp-Responsive Element-Binding Protein 4Transcript Induced In Spermiogenesis Protein 40Tisp40Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneMay Also Be Located In Golgi ApparatusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Androgen-Induced Basic Leucine Zipper Protein antibodyAnti-Aibzip antibodyAnti-Attaching To Cre-Like 1 antibodyAnti-Atce1 antibodyAnti-Cyclic Amp-Responsive Element-Binding Protein 4 antibodyAnti-Creb-4 antibodyAnti-Camp-Responsive Element-Binding Protein 4 antibodyAnti-Transcript Induced In Spermiogenesis Protein 40 antibodyAnti-Tisp40 antibodyAnti-Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-CREB3L4 antibodyAnti-AIBZIP antibodyAnti-CREB4 antibodyAnti-JAL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
