| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AGXT2 |
| Gene ID: |
64902 |
| Uniprot ID: |
AGT2_HUMAN |
| Immunogen Region: |
42-300 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 42-300 of human AGXT2 (NP_001293102.1). |
| Immunogen Sequence: |
LHTKPRMPPCDFMPERYQSL GYNRVLEIHKEHLSPVVTAY FQKPLLLHQGHMEWLFDAEG SRYLDFFSGIVTVSVGHCHP KVNAVAQKQLGRLWHTSTVF FHPPMHEYAEKLAALLPEPL KVIFLVNSGSEANELAMLMA RAHSNNIDIISFRGAYHGCS PYTLGLTNVGTYKMELPGGT GCQPTMCPDVFRGPWGGSHC RDSPVQTIRKCSCAPDCCQA KDQYIEQFKDTLSTSVAKS |
| Tissue Specificity | Expressed in the convoluted tubule in the kidney and in the liver hepatocytes (at protein level). |
| Function | Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. |
| Protein Name | Alanine--Glyoxylate Aminotransferase 2 - MitochondrialAgt 2(R-3-Amino-2-Methylpropionate--Pyruvate TransaminaseBeta-Alaat IiBeta-Alanine-Pyruvate AminotransferaseD-3-Aminoisobutyrate-Pyruvate AminotransferaseD-AibatD-Beta-Aminoisobutyrate-Pyruvate Aminotransferase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-73621 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Alanine--Glyoxylate Aminotransferase 2 - Mitochondrial antibodyAnti-Agt 2 antibodyAnti-(R-3-Amino-2-Methylpropionate--Pyruvate Transaminase antibodyAnti-Beta-Alaat Ii antibodyAnti-Beta-Alanine-Pyruvate Aminotransferase antibodyAnti-D-3-Aminoisobutyrate-Pyruvate Aminotransferase antibodyAnti-D-Aibat antibodyAnti-D-Beta-Aminoisobutyrate-Pyruvate Aminotransferase antibodyAnti-AGXT2 antibodyAnti-AGT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
