| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Type-1 angiotensin II receptor-associated protein is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGTRAP |
| Gene ID: | 57085 |
| Uniprot ID: | ATRAP_HUMAN |
| Specificity: | This antibody detects endogenous levels of AGTRAP at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human AGTRAP |
| Function | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. |
| Protein Name | Type-1 Angiotensin Ii Receptor-Associated ProteinAt1 Receptor-Associated Protein |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmic Vesicle MembranePresent In Perinuclear Vesicular MembranesEndoplasmic ReticulumGolgi And Endocytic Vesicles |
| Alternative Antibody Names | Anti-Type-1 Angiotensin Ii Receptor-Associated Protein antibodyAnti-At1 Receptor-Associated Protein antibodyAnti-AGTRAP antibodyAnti-ATRAP antibody |
Information sourced from Uniprot.org
