| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-G-protein-signaling modulator 1 (Internal) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPSM1 |
| Gene ID: | 26086 |
| Uniprot ID: | GPSM1_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | AGS3 Polyclonal Antibody detects endogenous levels of AGS3 protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human AGS3. |
| Post Translational Modifications | Phosphorylation regulates interaction with G(i/o) alpha. |
| Function | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. |
| Protein Name | G-Protein-Signaling Modulator 1Activator Of G-Protein Signaling 3 |
| Database Links | Reactome: R-HSA-418594 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideGolgi Apparatus MembraneCell Membrane |
| Alternative Antibody Names | Anti-G-Protein-Signaling Modulator 1 antibodyAnti-Activator Of G-Protein Signaling 3 antibodyAnti-GPSM1 antibodyAnti-AGS3 antibody |
Information sourced from Uniprot.org
