Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-AGA (24-346) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | AGA |
Gene ID: | 175 |
Uniprot ID: | ASPG_HUMAN |
Immunogen Region: | 24-346 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-346 of human AGA (NP_000018.2). |
Immunogen Sequence: | SSPLPLVVNTWPFKNATEAA WRALASGGSALDAVESGCAM CEREQCDGSVGFGGSPDELG ETTLDAMIMDGTTMDVGAVG DLRRIKNAIGVARKVLEHTT HTLLVGESATTFAQSMGFIN EDLSTTASQALHSDWLARNC QPNYWRNVIPDPSKYCGPYK PPGILKQDIPIHKETEDDRG HDTIGMVVIHKTGHIAAGTS TNGIKFKIHGRVGDSPIPGA GAYADDTAGAAAATGNGDI |
Post Translational Modifications | Cleaved into an alpha and beta chain by autocatalysis.this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. N-glycosylated. |
Function | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. |
Protein Name | N(4-(Beta-N-Acetylglucosaminyl-L-Asparaginase Aspartylglucosaminidase Glycosylasparaginase N4-(N-Acetyl-Beta-Glucosaminyl-L-Asparagine Amidase Cleaved Into - Glycosylasparaginase Alpha Chain - Glycosylasparaginase Beta Chain |
Database Links | Reactome: R-HSA-6798695 |
Cellular Localisation | Lysosome |
Alternative Antibody Names | Anti-N(4-(Beta-N-Acetylglucosaminyl-L-Asparaginase antibody Anti-Aspartylglucosaminidase antibody Anti-Glycosylasparaginase antibody Anti-N4-(N-Acetyl-Beta-Glucosaminyl-L-Asparagine Amidase Cleaved Into - Glycosylasparaginase Alpha Chain - Glycosylasparaginase Beta Chain antibody Anti-AGA antibody |
Information sourced from Uniprot.org