| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGA |
| Gene ID: | 175 |
| Uniprot ID: | ASPG_HUMAN |
| Immunogen Region: | 24-346 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-346 of human AGA (NP_000018.2). |
| Immunogen Sequence: | SSPLPLVVNTWPFKNATEAA WRALASGGSALDAVESGCAM CEREQCDGSVGFGGSPDELG ETTLDAMIMDGTTMDVGAVG DLRRIKNAIGVARKVLEHTT HTLLVGESATTFAQSMGFIN EDLSTTASQALHSDWLARNC QPNYWRNVIPDPSKYCGPYK PPGILKQDIPIHKETEDDRG HDTIGMVVIHKTGHIAAGTS TNGIKFKIHGRVGDSPIPGA GAYADDTAGAAAATGNGDI |
| Post Translational Modifications | Cleaved into an alpha and beta chain by autocatalysis.this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. N-glycosylated. |
| Function | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. |
| Protein Name | N(4-(Beta-N-Acetylglucosaminyl-L-AsparaginaseAspartylglucosaminidaseGlycosylasparaginaseN4-(N-Acetyl-Beta-Glucosaminyl-L-Asparagine Amidase Cleaved Into - Glycosylasparaginase Alpha Chain - Glycosylasparaginase Beta Chain |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-N(4-(Beta-N-Acetylglucosaminyl-L-Asparaginase antibodyAnti-Aspartylglucosaminidase antibodyAnti-Glycosylasparaginase antibodyAnti-N4-(N-Acetyl-Beta-Glucosaminyl-L-Asparagine Amidase Cleaved Into - Glycosylasparaginase Alpha Chain - Glycosylasparaginase Beta Chain antibodyAnti-AGA antibody |
Information sourced from Uniprot.org
