| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADRM1 |
| Gene ID: | 11047 |
| Uniprot ID: | ADRM1_HUMAN |
| Immunogen Region: | 108-407 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-407 of human ADRM1 (NP_008933.2). |
| Immunogen Sequence: | WMQEPKTDQDEEHCRKVNEY LNNPPMPGALGASGSSGHEL SALGGEGGLQSLLGNMSHSQ LMQLIGPAGLGGLGGLGALT GPGLASLLGSSGPPGSSSSS SSRSQSAAVTPSSTTSSTRA TPAPSAPAAASATSPSPAPS SGNGASTAASPTQPIQLSDL QSILATMNVPAGPAGGQQVD LASVLTPEIMAPILANADVQ ERLLPYLPSGESLPQTADEI QNTLTSPQFQQALGMFSAA |
| Post Translational Modifications | Ubiquitinated by UBE3C in response to proteotoxic stress. |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. |
| Protein Name | Proteasomal Ubiquitin Receptor Adrm1110 Kda Cell Membrane GlycoproteinGp110Adhesion-Regulating Molecule 1Arm-1Proteasome Regulatory Particle Non-Atpase 13Hrpn13Rpn13 Homolog |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1234176Reactome: R-HSA-1236974Reactome: R-HSA-1236978Reactome: R-HSA-174084Reactome: R-HSA-174113Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-180534Reactome: R-HSA-180585Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-211733Reactome: R-HSA-2467813Reactome: R-HSA-2871837Reactome: R-HSA-349425Reactome: R-HSA-350562Reactome: R-HSA-382556Reactome: R-HSA-450408Reactome: R-HSA-4608870Reactome: R-HSA-4641257Reactome: R-HSA-4641258Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5632684Reactome: R-HSA-5658442Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5678895Reactome: R-HSA-5687128Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69481Reactome: R-HSA-69601Reactome: R-HSA-75815Reactome: R-HSA-8852276Reactome: R-HSA-8854050Reactome: R-HSA-8939236Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-8948751Reactome: R-HSA-8951664Reactome: R-HSA-9010553Reactome: R-HSA-9020702Reactome: R-HSA-9604323Reactome: R-HSA-9755511Reactome: R-HSA-9762114Reactome: R-HSA-9824272Reactome: R-HSA-983168Reactome: R-HSA-9907900 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Proteasomal Ubiquitin Receptor Adrm1 antibodyAnti-110 Kda Cell Membrane Glycoprotein antibodyAnti-Gp110 antibodyAnti-Adhesion-Regulating Molecule 1 antibodyAnti-Arm-1 antibodyAnti-Proteasome Regulatory Particle Non-Atpase 13 antibodyAnti-Hrpn13 antibodyAnti-Rpn13 Homolog antibodyAnti-ADRM1 antibodyAnti-GP110 antibody |
Information sourced from Uniprot.org
