| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. |
| Function | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation. |
| Protein Name | Adhesion G Protein-Coupled Receptor L2Calcium-Independent Alpha-Latrotoxin Receptor 2Cirl-2Latrophilin Homolog 1Latrophilin-2Lectomedin-1 |
| Database Links | |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor L2 antibodyAnti-Calcium-Independent Alpha-Latrotoxin Receptor 2 antibodyAnti-Cirl-2 antibodyAnti-Latrophilin Homolog 1 antibodyAnti-Latrophilin-2 antibodyAnti-Lectomedin-1 antibodyAnti-ADGRL2 antibodyAnti-KIAA0786 antibodyAnti-LEC1 antibodyAnti-LPHH1 antibodyAnti-LPHN2 antibody |
Information sourced from Uniprot.org
