| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Dog/Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADCY3 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
FITC |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.68 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ADCY3 |
| Gene ID: |
109 |
| Uniprot ID: |
ADCY3_HUMAN |
| Immunogen: |
Synthetic peptide generated against a sequence unique to PAC3 protein. All peptides were amidated before conjugation. |
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis. |
| Post Translational Modifications | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3Atp Pyrophosphate-Lyase 3Adenylate Cyclase Type IiiAc-IiiAdenylate Cyclase - Olfactive TypeAdenylyl Cyclase 3Ac3 |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell ProjectionCiliumGolgi ApparatusAlso Detected In The CytoplasmClose To Lipid Droplets |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibodyAnti-Atp Pyrophosphate-Lyase 3 antibodyAnti-Adenylate Cyclase Type Iii antibodyAnti-Ac-Iii antibodyAnti-Adenylate Cyclase - Olfactive Type antibodyAnti-Adenylyl Cyclase 3 antibodyAnti-Ac3 antibodyAnti-ADCY3 antibodyAnti-KIAA0511 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
