Anti-ADAM11 antibody (600-650 aa) (STJ193787)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ADA11 at the amino acid range 600-650
General Information
| Short Description | Rabbit polyclonal anti-Disintegrin and metalloproteinase domain-containing protein 11 (600-650 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM11 |
| Gene ID | 4185 |
| Uniprot ID | ADA11_HUMAN |
| Immunogen | Synthesized peptide derived from the human ADA11 at the amino acid range 600-650 |
| Immunogen Region | 600-650 aa |
| Specificity | This antibody detects endogenous levels of ADA11 at Human/Mouse |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11Adam 11Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich ProteinMdc |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonCell ProjectionAxonLocalizes To Basket Cell Terminals And Pinceaux |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 11 antibodyAnti-Adam 11 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein antibodyAnti-Mdc antibodyAnti-ADAM11 antibodyAnti-MDC antibody |
Information sourced from Uniprot.org