Anti-ACIN1 antibody (1250-1330) (STJ190404)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal antibody anti-Apoptotic Chromatin Condensation Inducer In The Nucleus (1250-1330) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACIN1
Gene ID: 22985
Immunogen Region: 1250-1330
Specificity: ACIN1 polyclonal antibody (Apoptotic Chromatin Condensation Inducer In The Nucleus) binds to endogenous Apoptotic Chromatin Condensation Inducer In The Nucleus at the amino acid region 1250-1330.
Immunogen: Synthesized peptide derived from human protein at aa range 1250-1330
Post Translational Modifications Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1. Undergoes proteolytic cleavage.the processed form is active, contrary to the uncleaved form.
Function Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes).specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S).the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Protein Name Apoptotic Chromatin Condensation Inducer In The Nucleus
Database Links Reactome: R-HSA-111465
Cellular Localisation Nucleus
Nucleus Speckle
Phosphorylation On Ser-1180 By Srpk2 Redistributes It From The Nuclear Speckles To The Nucleoplasm
Alternative Antibody Names Anti-Apoptotic Chromatin Condensation Inducer In The Nucleus antibody
Anti-Acinus antibody
Anti-ACIN1 antibody
Anti-ACINUS antibody
Anti-KIAA0670 antibody

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