| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Histone H4-Lys12 (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | H4C1.H4C2.H4C3.H4C4.H4C5.H4C6.H4C8.H4C9.H4C11.H4C12.H4C13.H4C14.H4C15.H4C16 |
| Gene ID: | 121504/554313/8294/8359/8360/8361/8362/8363/8364/8365/8366/8367/8368/8370 |
| Uniprot ID: | H4_HUMAN |
| Immunogen Region: | 10-59 aa |
| Specificity: | Acetyl-Histone H4 (K12) Polyclonal Antibody detects endogenous levels of Histone H4 protein only when acetylated at K12. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Histone H4 around the acetylated site of Lys12 at the amino acid range 10-59 |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H4 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-1912408Reactome: R-HSA-201722Reactome: R-HSA-212300Reactome: R-HSA-2299718Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214842Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-427359Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-4551638Reactome: R-HSA-5250924Reactome: R-HSA-5334118Reactome: R-HSA-5578749Reactome: R-HSA-5617472Reactome: R-HSA-5625886Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-606279Reactome: R-HSA-68616Reactome: R-HSA-69473Reactome: R-HSA-73728Reactome: R-HSA-73772Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-912446Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9616222Reactome: R-HSA-9670095Reactome: R-HSA-9710421Reactome: R-HSA-977225 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone H4 antibodyAnti-H4C1 antibodyAnti-H4 antibodyAnti-A antibodyAnti-H4FA antibodyAnti-HIST1H4A.H4C2 antibodyAnti-H4 antibodyAnti-I antibodyAnti-H4FI antibodyAnti-HIST1H4B.H4C3 antibodyAnti-H4 antibodyAnti-G antibodyAnti-H4FG antibodyAnti-HIST1H4C.H4C4 antibodyAnti-H4 antibodyAnti-B antibodyAnti-H4FB antibodyAnti-HIST1H4D.H4C5 antibodyAnti-H4 antibodyAnti-J antibodyAnti-H4FJ antibodyAnti-HIST1H4E.H4C6 antibodyAnti-H4 antibodyAnti-C antibodyAnti-H4FC antibodyAnti-HIST1H4F.H4C8 antibodyAnti-H4 antibodyAnti-H antibodyAnti-H4FH antibodyAnti-HIST1H4H.H4C9 antibodyAnti-H4 antibodyAnti-M antibodyAnti-H4FM antibodyAnti-HIST1H4I.H4C11 antibodyAnti-H4 antibodyAnti-E antibodyAnti-H4FE antibodyAnti-HIST1H4J.H4C12 antibodyAnti-H4 antibodyAnti-D antibodyAnti-H4FD antibodyAnti-HIST1H4K.H4C13 antibodyAnti-H4 antibodyAnti-K antibodyAnti-H4FK antibodyAnti-HIST1H4L.H4C14 antibodyAnti-H4 antibodyAnti-N antibodyAnti-H4F2 antibodyAnti-H4FN antibodyAnti-HIST2H4 antibodyAnti-HIST2H4A.H4C15 antibodyAnti-H4 antibodyAnti-O antibodyAnti-H4FO antibodyAnti-HIST2H4B.H4C16 antibodyAnti-H4-16 antibodyAnti-HIST4H4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
