||WB, IHC, IF
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Acetyl-CoA carboxylase alpha is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||A synthetic peptide of human ACC1.
| Tissue Specificity || Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues.expressed at low level in pulmonary tissue.not detected in the liver. |
| Post Translational Modifications || Phosphorylation on Ser-1263 is required for interaction with BRCA1. Phosphorylation at Ser-80 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function || Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name || Acetyl-Coa Carboxylase 1Acc1Acetyl-Coenzyme A Carboxylase AlphaAcc-Alpha |
| Database Links || Reactome: R-HSA-163765Reactome: R-HSA-196780Reactome: R-HSA-200425Reactome: R-HSA-2426168Reactome: R-HSA-3371599Reactome: R-HSA-75105 |
| Cellular Localisation || CytoplasmCytosol |
| Alternative Antibody Names || Anti-Acetyl-Coa Carboxylase 1 antibodyAnti-Acc1 antibodyAnti-Acetyl-Coenzyme A Carboxylase Alpha antibodyAnti-Acc-Alpha antibodyAnti-ACACA antibodyAnti-ACAC antibodyAnti-ACC1 antibodyAnti-ACCA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance