• Western blot analysis of lysate from HeLa cells, using ACE2 antibody.

Anti-ACE2 antibody (Internal) (STJ91442)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal antibody anti-Angiotensin-Converting Enzyme 2 (Internal) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACE2
Gene ID: 59272
Uniprot ID: ACE2_HUMAN
Immunogen Region: Internal
Specificity: ACE2 polyclonal antibody (Angiotensin-Converting Enzyme 2) binds to endogenous Angiotensin-Converting Enzyme 2 at the amino acid region Internal.
Immunogen: The antiserum was produced against synthesized peptide derived from human ACE2 at amino acid range 416-465
Post Translational Modifications N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.
Function Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. Isoform 2: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Protein Name Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Homolog
Angiotensin-Converting Enzyme-Related Carboxypeptidase
Ace-Related Carboxypeptidase
Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-9678110
Reactome: R-HSA-9679191
Reactome: R-HSA-9694614
Cellular Localisation Processed Angiotensin-Converting Enzyme 2: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Apical Cell Membrane
Detected In Both Cell Membrane And Cytoplasm In Neurons
Isoform 2: Apical Cell Membrane
Alternative Antibody Names Anti-Angiotensin-Converting Enzyme 2 antibody
Anti-Angiotensin-Converting Enzyme Homolog antibody
Anti-Aceh antibody
Anti-Angiotensin-Converting Enzyme-Related Carboxypeptidase antibody
Anti-Ace-Related Carboxypeptidase antibody
Anti-Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 antibody
Anti-ACE2 antibody
Anti-UNQ868 antibody
Anti-PRO1885 antibody

Information sourced from Uniprot.org

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