||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody Anti-Angiotensin-converting enzyme 2 (Internal) is suitable for use in Western Blot and ELISA.
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||WB 1:500-1:2000ELISA 1:40000
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||ACE2 polyclonal antibody detects endogenous levels of ACE2 protein.
||Synthesized peptide derived from human ACE2.
| Post Translational Modifications || N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. |
| Function || Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. Isoform 2: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. |
| Protein Name || Angiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme HomologAcehAngiotensin-Converting Enzyme-Related CarboxypeptidaseAce-Related CarboxypeptidaseMetalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 |
| Database Links || Reactome: R-HSA-2022377Reactome: R-HSA-9678110Reactome: R-HSA-9679191Reactome: R-HSA-9694614 |
| Cellular Localisation || Processed Angiotensin-Converting Enzyme 2: SecretedCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmDetected In Both Cell Membrane And Cytoplasm In Neurons |
| Alternative Antibody Names || Anti-Angiotensin-Converting Enzyme 2 antibodyAnti-Angiotensin-Converting Enzyme Homolog antibodyAnti-Aceh antibodyAnti-Angiotensin-Converting Enzyme-Related Carboxypeptidase antibodyAnti-Ace-Related Carboxypeptidase antibodyAnti-Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 antibodyAnti-ACE2 antibodyAnti-UNQ868 antibodyAnti-PRO1885 antibody |
Information sourced from Uniprot.org
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