Anti-ACD antibody (1-220) (STJ114070)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACD (1-220) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACD |
| Gene ID | 65057 |
| Uniprot ID | ACD_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MPGRCQSDAAMRVNGPASRA PAGWTSGSLHTGPRAGRPRA QARGVRGRGLLLRPRPAKEL PLPRKGGAWAPAGNPGPLHP LGVAVGMAGSGRLVLRPWIR ELILGSETPSSPRAGQLLEV LQDAEAAVAGPSHAPDTSDV GATLLVSDGTHSVRCLVTRE ALDTSDWEEKEFGFRGTEGR LLLLQDCGVHVQVAEGGAPA EFYLQVDRFSLLPTEQPRLR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1). |
Additional Info
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. |
| Protein Name | Adrenocortical Dysplasia Protein HomologPot1 And Tin2-Interacting Protein |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Adrenocortical Dysplasia Protein Homolog antibodyAnti-Pot1 And Tin2-Interacting Protein antibodyAnti-ACD antibodyAnti-PIP1 antibodyAnti-PTOP antibodyAnti-TINT1 antibodyAnti-TPP1 antibody |
Information sourced from Uniprot.org