| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCG8 |
| Gene ID: | 64241 |
| Uniprot ID: | ABCG8_HUMAN |
| Immunogen Region: | 1-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human ABCG8 (NP_071882.1). |
| Immunogen Sequence: | MAGKAAEERGLPKGATPQDT SGLQDRLFSSESDNSLYFTY SGQPNTLEVRDLNYQVDLAS QVPWFEQLAQFKMPWTSPSC QNSCELGIQNLSFKVRSGQM LAIIGSSGCGRASLLDVITG RGHGGKIKSGQIWINGQPSS PQLVRKCVAHVRQHNQLLPN LTVRETLAFIAQMRLPRTFS QAQRDKRVEDVIAELRLRQC ADTRVGNMYVRGLSGGERRR VSIGVQLLWNPGILILDEP |
| Tissue Specificity | Predominantly expressed in the liver. Low expression levels in the small intestine and colon. Very low levels in other tissues, including brain, heart and spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 8Sterolin-2 |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-5679090Reactome: R-HSA-5679096Reactome: R-HSA-9029569 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 8 antibodyAnti-Sterolin-2 antibodyAnti-ABCG8 antibody |
Information sourced from Uniprot.org