| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IF/FC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ABCE1/RNase L (N-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ABCE1 |
| Gene ID: |
6059 |
| Uniprot ID: |
ABCE1_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_002931.2; NP_001035809.1 |
| Specificity: |
Reported variants represent identical protein: NP_002931.2 NP_001035809.1 |
| Immunogen Sequence: |
NHDKCKPKKCRQEC |
| Function | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. |
| Protein Name | Atp-Binding Cassette Sub-Family E Member 12'-5'-Oligoadenylate-Binding ProteinHuhp68Rnase L InhibitorRibonuclease 4 InhibitorRns4i |
| Database Links | Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family E Member 1 antibodyAnti-2'-5'-Oligoadenylate-Binding Protein antibodyAnti-Huhp68 antibodyAnti-Rnase L Inhibitor antibodyAnti-Ribonuclease 4 Inhibitor antibodyAnti-Rns4i antibodyAnti-ABCE1 antibodyAnti-RLI antibodyAnti-RNASEL1 antibodyAnti-RNASELI antibodyAnti-RNS4I antibodyAnti-OK antibodyAnti-SW-cl.40 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
