||Human, Rat, Mouse
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 3 (940-1020 Internal) is suitable for use in Western Blot and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000ELISA 1:5000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||ABCC3 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 3) binds to endogenous Atp-Binding Cassette Sub-Family C Member 3 at the amino acid region 940-1020 Internal.
||The antiserum was produced against synthesized peptide derived from human ABCC3 at amino acid range 971-1020
| Function || ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. |
| Protein Name || Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2Multi-Specific Organic Anion Transporter DMoat-DMultidrug Resistance-Associated Protein 3 |
| Database Links || Reactome: R-HSA-159418Reactome: R-HSA-382556 |
| Cellular Localisation || Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names || Anti-Atp-Binding Cassette Sub-Family C Member 3 antibodyAnti-Canalicular Multispecific Organic Anion Transporter 2 antibodyAnti-Multi-Specific Organic Anion Transporter D antibodyAnti-Moat-D antibodyAnti-Multidrug Resistance-Associated Protein 3 antibodyAnti-ABCC3 antibodyAnti-CMOAT2 antibodyAnti-MLP2 antibodyAnti-MRP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance