• Western blot analysis of HepG2 cells using MRP3 Polyclonal Antibody diluted at 1:2000
  • Western blot analysis of various cells using MRP3 Polyclonal Antibody diluted at 1:2000

Anti-ABCC3 antibody (940-1020 Internal) (STJ94206)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 3 (940-1020 Internal) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC3
Gene ID: 8714
Uniprot ID: MRP3_HUMAN
Immunogen Region: 940-1020 Internal
Specificity: ABCC3 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 3) binds to endogenous Atp-Binding Cassette Sub-Family C Member 3 at the amino acid region 940-1020 Internal.
Immunogen: The antiserum was produced against synthesized peptide derived from human ABCC3 at amino acid range 971-1020
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
Protein Name Atp-Binding Cassette Sub-Family C Member 3
Canalicular Multispecific Organic Anion Transporter 2
Multi-Specific Organic Anion Transporter D
Multidrug Resistance-Associated Protein 3
Database Links Reactome: R-HSA-159418
Reactome: R-HSA-382556
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 3 antibody
Anti-Canalicular Multispecific Organic Anion Transporter 2 antibody
Anti-Multi-Specific Organic Anion Transporter D antibody
Anti-Moat-D antibody
Anti-Multidrug Resistance-Associated Protein 3 antibody
Anti-ABCC3 antibody
Anti-CMOAT2 antibody
Anti-MLP2 antibody
Anti-MRP3 antibody

Information sourced from Uniprot.org

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