| Host: |
Rabbit |
| Applications: |
WB, IHC-P, IF, ICC, ELISA |
| Reactivity: |
Human, Rat, Mouse |
| Note: |
FOR RESEARCH USE ONLY (RUO). |
| Short Description: |
Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family B Member 10-Mitochondrial (410-490 Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCB10 |
| Gene ID: |
23456 |
| Uniprot ID: |
ABCBA_HUMAN |
| Immunogen Region: |
410-490 Internal |
| Specificity: |
ABCB10 polyclonal antibody (Atp-Binding Cassette Sub-Family B Member 10-Mitochondrial) binds to endogenous Atp-Binding Cassette Sub-Family B Member 10-Mitochondrial at the amino acid region 410-490 Internal. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human ABCB10 at amino acid range 441-490 |
| Function | Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner. May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria. Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 10 - MitochondrialAbc-Mitochondrial Erythroid ProteinAbc-Me ProteinAtp-Binding Cassette Transporter 10Abc Transporter 10 ProteinMitochondrial Atp-Binding Cassette 2M-Abc2 |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial antibodyAnti-Abc-Mitochondrial Erythroid Protein antibodyAnti-Abc-Me Protein antibodyAnti-Atp-Binding Cassette Transporter 10 antibodyAnti-Abc Transporter 10 Protein antibodyAnti-Mitochondrial Atp-Binding Cassette 2 antibodyAnti-M-Abc2 antibodyAnti-ABCB10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
