Anti-ABCA12 antibody (2170-2250) (STJ190576)


Current Stock:
Host: Rabbit
Applications: IHC-P, IF-P
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Glucosylceramide Transporter Abca12 (2170-2250) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA12
Gene ID: 26154
Immunogen Region: 2170-2250
Specificity: ABCA12 polyclonal antibody (Glucosylceramide Transporter Abca12) binds to endogenous Glucosylceramide Transporter Abca12 at the amino acid region 2170-2250.
Immunogen: Synthesized peptide derived from human protein at aa range 2170-2250
Function Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function. In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation. Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1. Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton. Also involved in lung surfactant biogenesis.
Protein Name Glucosylceramide Transporter Abca12
Atp-Binding Cassette Sub-Family A Member 12
Atp-Binding Cassette Transporter 12
Atp-Binding Cassette 12
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-5682294
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Localizes In The Limiting Membrane Of The Lamellar Granules (Lgs)
Trafficks From The Golgi Apparatus To The Lamellar Granules (Lgs) At The Cell Periphery In The Uppermost Granular Layer Keratinocytes Where Abca12-Positive Lgs Fuse With The Keratinocyte-Cell Membrane To Secrete Their Lipid Content To The Extracellular Space Of The Stratum Corneum
Co-Localizes Through The Golgi Apparatus To The Cell Periphery With Glucosylceramide
Alternative Antibody Names Anti-Glucosylceramide Transporter Abca12 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 12 antibody
Anti-Atp-Binding Cassette Transporter 12 antibody
Anti-Atp-Binding Cassette 12 antibody
Anti-ABCA12 antibody
Anti-ABC12 antibody

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