||WB, IHC, IF
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-ABCA1 (1870-2120) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||Recombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493.2).
| Tissue Specificity || Widely expressed, but most abundant in macrophages. |
| Post Translational Modifications || Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
| Function || Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs. |
| Protein Name || Phospholipid-Transporting Atpase Abca1Atp-Binding Cassette Sub-Family A Member 1Atp-Binding Cassette Transporter 1Abc-1Atp-Binding Cassette 1Cholesterol Efflux Regulatory Protein |
| Database Links || Reactome: R-HSA-1989781Reactome: R-HSA-5682113Reactome: R-HSA-8963896Reactome: R-HSA-9029569 |
| Cellular Localisation || Cell MembraneMulti-Pass Membrane ProteinEndosome |
| Alternative Antibody Names || Anti-Phospholipid-Transporting Atpase Abca1 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 1 antibodyAnti-Atp-Binding Cassette Transporter 1 antibodyAnti-Abc-1 antibodyAnti-Atp-Binding Cassette 1 antibodyAnti-Cholesterol Efflux Regulatory Protein antibodyAnti-ABCA1 antibodyAnti-ABC1 antibodyAnti-CERP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance