| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AANAT |
| Gene ID: | 15 |
| Uniprot ID: | SNAT_HUMAN |
| Immunogen Region: | 1-207 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
| Immunogen Sequence: | MSTQSTHPLKPEAPRLPPGI PESPSCQRRHTLPASEFRCL TPEDAVSAFEIEREAFISVL GVCPLYLDEIRHFLTLCPEL SLGWFEEGCLVAFIIGSLWD KERLMQESLTLHRSGGHIAH LHVLAVHRAFRQQGRGPILL WRYLHHLGSQPAVRRAALMC EDALVPFYERFSFHAVGPCA ITVGSLTFMELHCSLRGHPF LRRNSGC |
| Tissue Specificity | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. |
| Post Translational Modifications | cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. |
| Function | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| Protein Name | Serotonin N-AcetyltransferaseSerotonin AcetylaseAralkylamine N-AcetyltransferaseAa-Nat |
| Database Links | Reactome: R-HSA-209931 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serotonin N-Acetyltransferase antibodyAnti-Serotonin Acetylase antibodyAnti-Aralkylamine N-Acetyltransferase antibodyAnti-Aa-Nat antibodyAnti-AANAT antibodyAnti-SNAT antibody |
Information sourced from Uniprot.org