| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-5HT1B R is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 2000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
HTR1B |
| Gene ID: |
3351 |
| Uniprot ID: |
5HT1B_HUMAN |
| Specificity: |
Specific for 5HT1B receptor. |
| Immunogen: |
A synthetic peptide from mouse 5HT1B receptor conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Protein Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bS12Serotonin 1d Beta Receptor5-Ht-1d-BetaSerotonin Receptor 1b |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1b antibodyAnti-5-Ht-1b antibodyAnti-5-Ht1b antibodyAnti-S12 antibodyAnti-Serotonin 1d Beta Receptor antibodyAnti-5-Ht-1d-Beta antibodyAnti-Serotonin Receptor 1b antibodyAnti-HTR1B antibodyAnti-HTR1DB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
