| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-5HT1A (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:2, 500-1:5, 000DB: 1:50, 000ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Htr1a |
| Gene ID: |
24473 |
| Uniprot ID: |
5HT1A_RAT |
| Immunogen Region: |
200-250 |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytryptamine receptor 1A protein. |
| Tissue Specificity | Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1a antibodyAnti-5-Ht-1a antibodyAnti-5-Ht1a antibodyAnti-Serotonin Receptor 1a antibodyAnti-Htr1a antibodyAnti-5ht1a antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
