||IHC-P, IF, ELISA
||Human, Mouse, Rat
||Rabbit polyclonal anti-4E-BP1 antibody is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000
||4E-BP1 polyclonal antibody detects endogenous levels of 4E-BP1 protein.
||Synthesized peptide derived from human 4E-BP1 around the non-phosphorylation site of T36.
| Function || Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Protein Name || Eukaryotic Translation Initiation Factor 4e-Binding Protein 14e-Bp1Eif4e-Binding Protein 1Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1Phas-I |
| Database Links || Reactome: R-HSA-166208Reactome: R-HSA-72662 |
| Alternative Antibody Names || Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 antibodyAnti-4e-Bp1 antibodyAnti-Eif4e-Binding Protein 1 antibodyAnti-Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 antibodyAnti-Phas-I antibodyAnti-EIF4EBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance