Anti-2A5G antibody (STJ191383)

SKU:
STJ191383

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal anti-2A5G antibody is suitable for use in Western Blot and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purification: 2A5G antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Specificity: 2A5G polyclonal antibody detects endogenous levels of protein.
Uniprot ID: 2A5G_HUMAN
Gene ID: 5527
Gene Symbol: PPP2R5C
Immunogen: Synthesized peptide derived from human 2A5G protein.
Immunogen Region: 360-440aa
Post Translational Modifications Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Protein Name Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform
Pp2a B Subunit Isoform B'-Gamma
Pp2a B Subunit Isoform B56-Gamma
Pp2a B Subunit Isoform Pr61-Gamma
Pp2a B Subunit Isoform R5-Gamma
Renal Carcinoma Antigen Ny-Ren-29
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-389513
Reactome: R-HSA-432142
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-5663220
Reactome: R-HSA-5673000
Reactome: R-HSA-5675221
Reactome: R-HSA-6804757
Reactome: R-HSA-6811558
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Nucleus
Chromosome
Centromere
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform antibody
Anti-Pp2a B Subunit Isoform B'-Gamma antibody
Anti-Pp2a B Subunit Isoform B56-Gamma antibody
Anti-Pp2a B Subunit Isoform Pr61-Gamma antibody
Anti-Pp2a B Subunit Isoform R5-Gamma antibody
Anti-Renal Carcinoma Antigen Ny-Ren-29 antibody
Anti-PPP2R5C antibody
Anti-KIAA0044 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance