| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | YWHAG |
| Gene ID: | 7532 |
| Uniprot ID: | 1433G_HUMAN |
| Immunogen Region: | 100-200 |
| Immunogen Sequence: | VLSLLDNYLIKNCSETQYES KVFYLKMKGDYYRYLAEVAT GEKRATVVESSEKAYSEAHE ISKEHMQPTHPIRLGLALNY SVFYYEIQNAPEQACHLAKT A |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human 14-3-3 gamma (P61981). |
| Tissue Specificity | Highly expressed in brain, skeletal muscle, and heart. |
| Post Translational Modifications | Phosphorylated by various PKC isozymes. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1. Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes. Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria. |
| Protein Name | 14-3-3 Protein GammaProtein Kinase C Inhibitor Protein 1Kcip-1 Cleaved Into - 14-3-3 Protein Gamma - N-Terminally Processed |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-8854518Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmCytosolMitochondrion MatrixTranslocates To The Mitochondrial Matrix Following Induction Of Malm (Mitochondrial Protein Catabolic Process) |
| Alternative Antibody Names | Anti-14-3-3 Protein Gamma antibodyAnti-Protein Kinase C Inhibitor Protein 1 antibodyAnti-Kcip-1 Cleaved Into - 14-3-3 Protein Gamma - N-Terminally Processed antibodyAnti-YWHAG antibody |
Information sourced from Uniprot.org
