| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TRPM8 Positive Control for STJ503412 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Trpm8 |
| Gene ID: |
171384 |
| Uniprot ID: |
TRPM8_RAT |
| Specificity: |
This is positive control is recommended for use in combination with TRPM8 antibody STJ503412. |
| Tissue Specificity | Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons. |
| Function | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel.its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality. |
| Peptide Name | Transient Receptor Potential Cation Channel Subfamily M Member 8Cold Menthol Receptor 1 |
| Database Links | Reactome: R-RNO-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftLipid Raft Association Of Trpm8 Modulates Channel Activity |
| Alternative Peptide Names | Transient Receptor Potential Cation Channel Subfamily M Member 8 proteinCold Menthol Receptor 1 proteinTrpm8 proteinCmr1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
