| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. |
| Function | Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment. |
| Peptide Name | Asc-Type Amino Acid Transporter 1Asc-1Solute Carrier Family 7 Member 10 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes |
| Alternative Peptide Names | Asc-Type Amino Acid Transporter 1 proteinAsc-1 proteinSolute Carrier Family 7 Member 10 proteinSLC7A10 proteinASC1 protein |
Information sourced from Uniprot.org
