| Tissue Specificity | Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen. |
| Post Translational Modifications | Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1. |
| Function | Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation. Isoform 2: Lacks channel activity. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 4Calcium-Activated Non-Selective Cation Channel 1Long Transient Receptor Potential Channel 4Ltrpc-4Ltrpc4Mls2sMelastatin-Like 2 |
| Database Links | Reactome: R-RNO-3295583 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumGolgi ApparatusIsoform 2: Cell MembraneMainly Integrated Into The Er/Golgi Complex And Is Rarely Found In The Plasma Membrane |
| Alternative ELISA Names | Transient Receptor Potential Cation Channel Subfamily M Member 4 ELISA kitCalcium-Activated Non-Selective Cation Channel 1 ELISA kitLong Transient Receptor Potential Channel 4 ELISA kitLtrpc-4 ELISA kitLtrpc4 ELISA kitMls2s ELISA kitMelastatin-Like 2 ELISA kitTrpm4 ELISA kitLtrpc4 ELISA kit |
| output | |
Information sourced from Uniprot.org
